Needle-free connectors have been introduced into clinical practice to prevent accidental needle stick injuries and related blood-borne infections. The needle-free connector includes a separating diaphragm device and a mechanical valve. According to the function of the internal diaphragm or valve, mechanical valves are divided into neutral, negative and positive types. Some studies have reported that mechanical valves, especially positive displacement valves, can reduce thrombotic catheter blockage based on their valve function to prevent blood from returning to the intravascular catheter.


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